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Nederlands Buitenlands   Alles  Titel  Auteur  ISBN        
Levende natuur
Biologie algemeen

Naidong Weng

Targeted Biomarker Quantitation by LC-MS

€ 195.60


The first book to offer a blueprint for overcoming the challenges to successfully quantifying biomarkers in living organisms 

The demand among scientists and clinicians for targeted quantitation experiments has experienced explosive growth in recent years.





Taal / Language : English

Inhoudsopgave:

List of Contributors

Preface

Abbreviations

Chapter  Authors

Part 1. Overview

1.  Overview of Targeted Quantitation of Biomarkers and Its Application

2.  Translational Application of Biomarkers

3.  Current Regulatory Guidance Pertaining Biomarker Assay Establishment and Industrial Practice of Fit-for-Purpose and Tiered Approach

4.  Modern Liquid Chromatography and Mass Spectrometry for Targeted Biomarker Quantitation

5.  Comparison between LC-MS and Ligand Binding Assay Approaches for Biomarker Quantification

6.  Sample Preparation Methods for Targeted Biomarker Quantification by LC-MS

7.  Overcome the Endogenous Levels in Biomarker Quantitation Using LC-MS

Part 2. Challenges and Approaches

8.  Sample Collection for Targeted Biomarker Quantitation by LC-MS

9.  Nonspecific Binding in LC MS Bioanalysis

10.  Strategies for Improving Sensitivity for Targeted Quantitation by LC-MS

11.  Strategies to Improve Specificity for Targeted Biomarker Quantitation by LC-MS

12.  Biomarker Quantitation Using Relative Approaches

13.  Targeted Quantification of Amino Acid Biomarkers Using LC-MS

Part 3. Applications

14.  Targeted Quantification of Peptide Biomarkers A Case Study of Amyloid Peptides

15.  Targeted Protein Biomarker Quantitation by LC-MS

16.  Glycoprotein Biomarkers

17.  Targeted Lipid Biomarker Quantitation Using Liquid Chromatography Mass Spectrometry (LC-MS)

18.  Targeted LC-MS Quantification of Androgens and Estrogens for Biomarker Development

19.  Steroid Biomarkers

20.  Bile Acids as Biomarkers

21.  Biomarkers for Vitamin Status and Deficiency LC-MS Based Approach

22.  Quantitation of acyl-coenzyme A thioesters as metabolic biomarkers

23.  Neurotransmitter Biomarkers

24.  Targeted Quantification of Carbohydrate Biomarkers Using LC-MS

25.  Nucleoside/Nucleotide Biomarkers

26.  LC-MS of RNA Biomarkers

Extra informatie: 
Hardback
464 pagina's
Januari 2017
1315 gram
274 x 222 x 31 mm
John Wiley and Sons Ltd gb

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