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Richardt, Andre Decontamination of Warfare Agents
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Decontamination of Warfare Agents

Enzymatic Methods for the Removal of B/C Weapons

€ 197.95

Based on previously inaccessible results of military research, this practice-oriented handbook introduces the use of enzymes for fast and efficient decontamination of


Taal / Language : English

Inhoudsopgave:
Foreword.

Preface.

List of Contributors.

1 The History of Biological Warfare (Friedrich Frischknecht).

1.1 Introduction.

1.2 Pre Twentieth Century Examples.

1.3 From World War I to World War II.

1.4 Secret Projects and Cold War Allegations.

1.5 Towards the Twenty fi rst Century: Madmen on the Run.

1.6 Future Threats Science or Fiction?

1.7 Acknowledgements.

2 History of Chemical Warfare (André Richardt).

2.1 Introduction.

2.2 The Beginning.

2.3 The Rise of a New Age From WW I to WW II.

2.4 The Italian Ethiopian War.

2.5 Japanese Invasion of China.

2.6 The First Nerve Agents.

2.7 Living with the Danger of Chemical Warfare From WW II to 2000.

2.8 The Running Madmen Emergence of Chemical Terrorism.

3 Monitoring and New Threats of Chemical/Biological Weapons (André Richardt and Roland Dierstein).

3.1 Introduction.

3.2 International Conventions.

3.3 Chemical/Biological Agent Characteristics.

3.4 Asymmetric Warfare.

3.5 Threat Scenarios for Chemical/biological Weapons.

4 Biological Warfare Agents (Heiko Russmann and André Richardt).

4.1 Introduction.

4.2 Biological Warfare Agents and Biological Weapons: A Division.

4.3 Types of Biological Warfare Agents.

4.4 The Dirty Dozen .

5 Chemical Warfare Agents (Alexander Grabowski, André Richardt and Marc Michael Blum).

5.1 Introduction.

5.2 Chemical Warfare Agents and Chemical Weapons: A Differentiation.

5.3 Classifi cation.

5.4 Summary.

6 Decontamination of Biological Warfare Agents (Bärbel Niederwöhrmeier and André Richardt).

6.1 Introduction.

6.2 Resistance of Spores Against Stress and Basics of Inactivation.

6.3 Technical Methods for Decontamination of Spore Infested Buildings.

6.4 Is Clean Clean Enough or How Clean Is Clean Enough?

7 Decontamination of Chemical Warfare Agents (Hans Jürgen Altmann and André Richardt).

7.1 Introduction.

7.2 Defi nition of Decontamination.

7.3 CW Agent Decontamination.

7.4 Decontamination Procedures.

7.5 Summary and Conclusions.

8 A Short Introduction to Enzyme Catalysis (Marc Michael Blum).

8.1 Introduction.

8.2 Thermodynamic Equilibrium, Reaction Velocities and the Need for Catalysis.

8.3 Proteins and Structure A Prerequisite for Enzyme Function.

8.4 From Ligand Binding to Enzyme Activity.

8.5 Enzyme Classifi cation.

8.6 Kinetics of Enzyme Reactions.

8.7 Enzymes for Industrial Applications.

9 Hydrolytic Enzymes for Chemical Warfare Agent Decontamination (Marc Michael Blum and André Richardt).

9.1 Problematic Warfare Agents and Pathways for Detoxifi cation.

9.2 Hydrolysis of Warfare Agents.

9.3 Early Examples of Enzymatic Decontamination.

9.4 Current Hydrolytic Enzyme Systems.

9.5 Squid DFPase.

9.6 Paraoxonase (PON).

9.7 Organophosphorus Hydrolase (OPH) from Pseudomonas diminuta.

9.8 Organophosphorus Acid Anhydrolase (OPAA) from Alteromonas.

9.9 Haloalkane Dehalogenase from LinB from Sphingobium Japonicum.

9.10 Carrier Systems for Hydrolytic Enzymes.

9.11 Technical Decontamination with DFPase An Example.

9.12 Conclusions and Outlook.

10 Laccases Oxidative Enzymes for Bioremediation of Xenotics and Inactivation of Bacillus Spores (Bärbel Niederwöhrmeier, Lars Ostergaard, André Richardt and Steffen Danielsen).

10.1 Introduction.

10.2 Nomenclature.

10.3 Distribution of Laccases.

10.4 General Structure, Biochemical and Active Site Properties of Laccases.

10.5 Catalytic Mechanism of Laccases.

10.6 Laccase Mediator System (LMS).

10.7 Heterologous Expression of Laccases.

10.8 Laccase Applications.

10.9 Inactivation of Spores.

10.10 Conclusions.

11 Medical Aspects of Chemical Warfare Agents (Kai Kehe, Franz Worek and Horst Thiermann).

11.1 Introduction.

11.2 Decontamination.

11.3 Nerve Agents.

11.4 Alkylating Agents.

11.5 Outlook.

12 Microemulsions: A Versatile Carrier for Decontamination Agents (Thomas Hellweg, Stefan Wellert, S.J. Mitchell and André Richardt).

12.1 Introduction.

12.2 Requirements for Decontaminants.

12.3 Basic Principles.

12.4 Investigation of the Microemulsion Structure.

12.5 Application Related Results.

12.6 Conclusions.

13 Immobilization of Enzymes (Birgit Hülseweh, André Richardt and Bernd Niemeyer).

13.1 Introduction.

13.2 History of Immobilization Technologies.

13.3 Heterogeneous Bio systems Benefi ts and Drawbacks.

13.4 Basic Technologies for the Immobilization and Methods for the Characterization of Heterogeneous Bio systems.

13.5 Applications of Immobilized Enzymes for Detoxifi cation, Decontamination and Detection of Chemical Warfare Agents.

13.6 Conclusions and Outlook.

14 Road Ahead (Marc Michael Blum, Heiko Russmann, and André Richardt).

14.1 Introduction.

14.2 Developments in Science.

14.3 Bioterrorism.

14.4 Agricultural Biowarfare.

14.5 Public Health Response to Biological and Chemical Weapons.

14.6 State of the Current Decontamination Technology.

14.7 Road ahead for Enzymatic Decontamination.

Index.
Extra informatie: 
Hardback
311 pagina's
Januari 2008
710 gram
235 x 171 x 19 mm
Wiley VCH de

Levertijd: 5 tot 11 werkdagen